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Methazonic acid
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Substance index - selected nitrocompounds tested by our group /
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CAS: 5653-21-4
MW: 104.065
Brutto formula: C2H4N2O3
M.p. [oC]: 70-71 [Ref.]
UV/VIS [nm]: 298 [Ref.]
1H-NMR [ppm]: 7.05 (t, 1H), 4.65 (d, 2H) [Ref.]
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Preparation [Ref.]:
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Nitromethane is added to a 50% aqueous solution of sodium hydroxide while maintaining the temperature between 45 and 50oC. The solution is then chilled to 0oC, and concentrated hydrochloric acid is added, keeping the temperature below 5 oC. The precipitated yellow solid is filtered, pressed on a clay plate, and dissolved in diethyl ether, followed by drying over anhydrous calcium chloride. The drying agent is filtered, and the ether evaporated to dryness yielding 50% of methazonic acid.
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Applications:
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Novel synthesis scheme and in vitro antimicrobial evaluation of a panel of (E)-2-aryl-1-cyano-1-nitroethenes
Boguszewska-Czubara A, Łapczuk-Krygier A., Rykała K., Biernasiuk A., Wnorowski A, Popiołek Ł., Maziarka A., Hordyjewska A., Jasiński R.
Journal of Enzyme Inhibition and Medicinal Chemistry, [in press] DOI: 10.3109/14756366.2015.1070264 |
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Similar compounds: nitroacetonitrile
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